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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedures based on scientific principles and standards, limited documentation, acceptable for assessment.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 870.2400 (Acute Eye Irritation)
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-aminophenol
EC Number:
204-616-2
EC Name:
4-aminophenol
Cas Number:
123-30-8
Molecular formula:
C6H7NO
IUPAC Name:
4-aminophenol

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
water
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution):2.5% w/v suspension
Observation period (in vivo):
1, 24,and 72 hrs after instillation
Number of animals or in vitro replicates:
3 rabbits

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: primary irritation index
Basis:
mean
Time point:
other: 72 hrs
Score:
0.2
Reversibility:
fully reversible
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
other: results provided for primary irritation index only
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
other: results provided for primary irritation index only
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
other: results provided for primary irritation index only
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
other: results provided for primary irritation index only
Irritant / corrosive response data:
primary irritation index was 0.2.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
4-aminophenol was a slight reversible irritant to the rabbit eye.