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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Microdetermination and dynamic aspects of in vivo alkyl lead compounds
Author:
Hayakawa, K.
Year:
1972
Bibliographic source:
Japanes Journal Hyg. Vol 26, pp 526-535

Materials and methods

Objective of study:
distribution
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No detail of test method is available
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Mice were also used

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Main ADME resultsopen allclose all
Type:
distribution
Results:
Blood: Max conc after 1 hour exposure
Type:
distribution
Results:
Liver: Max conc after 3 hours exposure
Type:
distribution
Results:
Kidney: 11% of total dose after 20 hours exposure

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:
The maximum concentration is reached in the blood and liver after 1 -3 hours. In the kidney about 11% of the exposure dose accumulates within 20 hours.

After i.p administration, maximium tissue levels in the whole animal of TEL in the form of TriEL were measured after 3 days in mice and 3 -5 days in rats.

Any other information on results incl. tables

Biological half-lives after ip

 Substance  Organ  Half Life (in days)
 TEL Whole animal (mouse)  3
  Whole animal (rat)  < 1
TriEL  Whole animal (mouse)  2
  Blood (rat)  10
  Blood (mouse)  3 - 5
  Liver/kidney (rat)   15
  Brain (rat)  7 - 8
          

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
The maximum concentration is reached in the blood and liver after 1 -3 hours. Maximium tissue levels in the whole animal of TEL in the form of TriEL were measured after 3 days in mice and 3 -5 days in rats. Tetraalkyl lead accumulates heavily in the brain, liver and kidney
Executive summary:

The maximum concentration is reached in the blood and liver after 1 -3 hours. In the kidney about 11% of the exposure dose accumulates within 20 hours.

Biological half life data is presented for both TEL and it's degradation product TriEL. Values for TEL were less than 1 day for rats and 3 days for mice.

After i.p administration, maximium tissue levels in the whole animal of TEL in the form of TriEL were measured after 3 days in mice and 3 -5 days in rats.

Tetraalkyl lead accumulates heavily in the brain, liver and kidney