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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., Zeiger, E.
Year:
1986
Bibliographic source:
Environ. Mutagen. Vol 8, pp 1-119

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EPA OPPTS 870.5265 (The Salmonella typhimurium Bacterial Reverse Mutation Test)
Principles of method if other than guideline:
TEL was investigated in the Ames test on Salmonella typhimurium TA 98, TA 100 and TA 1537
GLP compliance:
no
Remarks:
test completed before GLP implementation
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Metabolic activation system:
Rat/Hamster liver
Test concentrations with justification for top dose:
1-1000 µg TEL/plate dissolved in DMSO (0/10/33/100/333/1000 µg/Plate)

Details on test system and experimental conditions:
Ames test

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

TEL at dose levels of 1-1000 µg/plate in DMSO, proved to be non mutagenic in an Ames test on Salmonella typhimurium TA 98, TA 100 and TA 1537
Executive summary:

TEL at dose levels of 1-1000 µg/plate in DMSO, proved to be non mutagenic in an Ames test on Salmonella typhimurium TA 98, TA 100 and TA 1537