Registration Dossier

Administrative data

Endpoint:
immunotoxicity: oral
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Blakley, B.R., Sisodia, C.S., Mukkur, T.K.
Year:
1980
Bibliographic source:
Toxicol. Appl. Pharmacol. 52, 245-254

Materials and methods

Principles of method if other than guideline:
The influence of TEL on humoral immunity was studied in  Swiss-Cross mice.  Groups of 8-10 animals were given 0.5 -  10 ppm Pb/l (0.9 - 17 mg TEL/l) in their drinking water for  three weeks.  Haemagglutination, radial immunodiffusion and  Cunningham Plaque Assay tests were performed.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
Swiss

Administration / exposure

Route of administration:
oral: drinking water
Duration of treatment / exposure:
3 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 -  10 ppm Pb/l (0.9 - 17 mg TEL/l)
Basis:

No. of animals per sex per dose:
Groups of 8-10 animals 

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
0.5 ppm
Based on:
act. ingr.
Remarks:
Lead

Any other information on results incl. tables

In all tests TEL caused immunosuppressive effects with a maximum effect at 2.0 ppm.

Applicant's summary and conclusion