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EC number: 201-075-4 | CAS number: 78-00-2
TEL at dose levels of 1-1000 µg/plate in DMSO, proved to be non mutagenic in an Ames test on Salmonella typhimurium TA 98, TA 100 and TA 1537
No evidence of mutagenic activity was seen in two good quality Ames tests, using TEL concentrations of 1-1000 µg/plate in DMSO and 1-100 µg/plate in ethanol in Salmonella typhimurium strains TA 98, TA 100 and TA 1537, with and without mammalian metabolic activation (S9) (Mortelmans et al. 1986). A similar study on the analogous substance tetramethyl lead (TML) was also negative (Ames, 1975).
Investigations on Drosophilia melanogaster showed TriEL (a degradation product of TEL) to cause disturbances in nuclear division. (Ramel et al 1979)
Investigations on mice showed at maximally tolerated doses TEL did not promote a dominant lethal response (Kennedy et al 1971)
TEL was negative in two good-quality Ames tests at up to 1000 µg/plate, with and without S9. Investigations on mice showed at maximally tolerated doses TEL did not promote a dominant lethal response Kennedy et al 1971) TEL is not classified as mutagenic in Annex I of the EU DSD or according to CLP regulations.
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