Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment. Reliability assessment as per that quoted in IUCLID 4 (2000) data review

Data source

Reference
Reference Type:
publication
Title:
The penetration of lead through the skin
Author:
Laug, Kunze
Year:
1948
Bibliographic source:
J. Ind. Hyg. Toxicol. 30, pp 256-259

Materials and methods

Principles of method if other than guideline:
Rats (300 - 350 g weight) were contaminated over 29 cm2 skin with TEL at a dose level of 106 mg Pb per rat and observed for adsorption effects over 24 hours
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
300 - 350 g weight

Administration / exposure

Type of coverage:
open
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
Rats were contaminated over 29 cm2 skin with TEL at a dose level of 106 mg Pb per rat

Results and discussion

Signs and symptoms of toxicity:
yes
Percutaneous absorption
Dose:
106mg Pb
Parameter:
percentage
Absorption:
ca. 6.5 %
Remarks on result:
other: 24h
Remarks:
6.5% of the applied amount adsorbed into the body of the rats. It is believed that a large proportion (90%) of TEL evaporates from the skin and only a small portion is actually absorbed by the skin.

Applicant's summary and conclusion

Conclusions:
6.5% of the applied amount adsorbed into the body of the rats. It is believed that a large proportion (90%) of TEL evaporates from the skin and only a small portion is actually absorbed by the skin.
Executive summary:

Rats (300 - 350 g weight) were contaminated over 29 cm2 skin with TEL at a dose level of 106 mg Pb per rat and observed for adsorption effects over 24 hours. TEL penetrates through the skin and is then distributed in the body tissues. 6.5% of the applied amount adsorbed into the body of the rats. It is believed that a large proportion (90%) of TEL evaporates from the skin and only a small portion is actually absorbed by the skin.