Registration Dossier
Registration Dossier
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EC number: 216-823-5 | CAS number: 1675-54-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Report date:
- 1949
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- dermal sensitization study in humans
- GLP compliance:
- no
Test material
- Reference substance name:
- 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
- EC Number:
- 500-033-5
- EC Name:
- 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
- Cas Number:
- 25068-38-6
- Molecular formula:
- (C15 H16 O2 . C3 H5 Cl O)x
- IUPAC Name:
- 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
- Reference substance name:
- 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
- EC Number:
- 216-823-5
- EC Name:
- 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
- Cas Number:
- 1675-54-3
- Molecular formula:
- C21H24O4
- IUPAC Name:
- 2,2'-[propane-2,2-diylbis(4,1-phenyleneoxymethylene)]dioxirane
- Details on test material:
- Identified only as L645-139 and s-127035
Constituent 1
Constituent 2
Method
- Type of population:
- general
- Subjects:
- 100 men and 100 women
- Controls:
- no control group
- Route of administration:
- dermal
- Details on study design:
- The test material, as a 10% solution in butylcarbitol acetate as placed on the skin of the backs of 100 men and 100 women and allowed to remain for 5 days. Three weeks after removal of the patches, the same material was again applied to the same subjects for 48 hours. The occurrence of a more intense reaction or of a greater incidence of reactions after the second application is indicative that sensitization has occurred and that the test material is a sensitizer.
Results and discussion
- Results of examinations:
- None of the males or females reacted to either the first or second application of the test material.
Any other information on results incl. tables
These results suggest that the test material is neither a skin sensitizer nor a skin irritant of significance.
Applicant's summary and conclusion
- Conclusions:
- None of the males or females reacted to either the first or second application of the test material.
- Executive summary:
The dermal sensitization potential of the test material was examined in 100 males and 100 females. None of the males or females reacted to either the first or second application of the test material. These results suggest that the test material is neither a skin sensitizer nor a skin irritant of significance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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