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EC number: 216-823-5
CAS number: 1675-54-3
A number of chronic toxicity/carcinogenicity
studies have been conducted. In the most recently conducted studies, the
NOAEL was 15 and 100 mg/kg/day in male and female rats, respectively,
following two years oral administration of BADGE. Decreased body weight
and an enlarged cecum were observed in male rats at 15 mg/kg/day in the
oral study. In the dermal chronic toxicity/carcinogenicity studies, male
mice and female rats were used. The systemic NOEL was 1 mg/kg/day in
female rats and 100 mg/kg/day in male mice. Histopathologic changes were
observed in the liver of female rats administered 10 and 100 mg/kg/day.
These changes were attributed to ingestion since the test material was
not occluded. In male mice the NOEL at the application site was 0.1
mg/kg/day. Epidermal hyperplasia, chronic dermal inflammation and
epidermal crusts were observed histopathologically at dosages of 10 and
100 mg/kg/application in male mice.
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