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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Type of study / information:
cytogenic information
Endpoint addressed:
genetic toxicity
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Cytogenetic evaluation of peripheral lymphocytes of workers exposed to epoxy resins
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
epoxy resins of the BADGE-type

Method

Details on study design:
Cytogenic evaluation was performed of peripheral lymphocytes from 18 workers currently exposed to epoxy resins of the BADGE-type. Nine workers were exposed to low molecular weights (<900), and 9 to higher molecular weight resins (average ~2000). Results were compared to an equal number of control individuals matched for sex and age.
Exposure assessment:
not specified
Details on exposure:
Nine workers were exposed to low molecular weights (<900), and 9 to higher molecular weight resins (average ~2000).

Results and discussion

Results:
There was no difference in chromosomal aberration frequency between the controls and the groups exposed to epoxy resin. The study gave no indication that exposure to epoxy resin produces visible damage to the chromosomes.

Any other information on results incl. tables

The present study did not give any indication that occupational exposure to low or high molecular epoxy resin produces visible chromosomal damage.

Applicant's summary and conclusion

Conclusions:
There was no difference in chromosomal aberration frequency between the controls and the groups exposed to epoxy resin.
Executive summary:

Cytogenetic evaluation was performed of peripheral lymphocytes from 18 workers currently exposed to epoxy resins of the type diglycidyl ether bisphenol-A (DGEBA). 9 workers were exposed to low molecular (average MW <900) and 9 to high molecular (average MW about 2000) epoxy resins. The results were compared with an equal number of control individuals matched for sex and age. There was no difference in chromosomal aberration frequency between the controls and the groups exposed to epoxy resin. Thus, this study gave no indication that exposure to epoxy resin produces visible damage to the chromosomes.