Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
  • IUPAC name: 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane
  • Other names
EC / List no.:
216-823-5
CAS no.:
1675-54-3
Index number:
603-073-00-2
Molecular formula:
C21H24O4
SMILES:
CC(C)(C1=CC=C(OCC2CO2)C=C1)C1=CC=C(OCC2CO2)C=C1
InChI:
InChI=1/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
Type of substance:
Multi constituent substance
Origin:
Organic
Registered compositions:
34
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation, causes skin irritation and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 1110 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Aquatic Chronic 2 H411
Aquatic Acute 1 H400
Aquatic Chronic 3 H412
Water-react. 3 H261
Acute Tox. 4 H302
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 74 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, formulation of mixtures, manufacturing of the substance and in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and vehicles. This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), plastic (e.g. food packaging and storage, toys, mobile phones), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay, adhesives and sealants and semiconductors. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: building & construction work and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: machinery and vehicles, plastic products and electrical, electronic and optical equipment.

This substance is used in the following activities or processes at workplace: transfer of chemicals, treatment of articles by dipping and pouring, roller or brushing applications, non-industrial spraying, hand mixing with intimate contact only with personal protective equipment available, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: polymers, adhesives and sealants, coating products and fillers, putties, plasters, modelling clay. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers, coating products and adhesives and sealants. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging, building & construction work and mining. This substance is used for the manufacture of: machinery and vehicles, plastic products, electrical, electronic and optical equipment and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, roller or brushing applications, treatment of articles by dipping and pouring, industrial spraying and laboratory work.

Release to the environment of this substance can occur from industrial use: in the production of articles, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not get in eyes, on skin, or on clothing; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • 3M Wroclaw Sp.z.o.o., ul. Kowalska 143 51-424 Wroclaw Poland
  • ADEKA Europe GmbH, Berliner Allee 22 40212 Düsseldorf Germany
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Atul Europe Limited, 1| B Dean Row Court, Summerfields village centre, Dean Row road, SK9 2 TB Wilmslow Cheshire United Kingdom
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • B.I.G. - OR634, Technische Schoolstraat 43A 2440 Geel Belgium
  • BIOTRONIK SE & Co. KG, Woermannkehre 1 12359 Berlin Germany
  • Blue Cube Chemicals Italy S.r.l.  , via Francesco Albani 65 20148 Milano Italy
  • Blue Cube Germany Assets GmbH & Co. KG, Buetzflether Sand 2 21683 Stade Germany
  • Blue Cube Netherlands B.V., Axelsedam 3a 4531HH Terneuzen Netherlands
  • Blue Cube Netherlands B.V. – OR1, Axelsedam 3a 4531HH Terneuzen Netherlands
  • Blue Cube Netherlands B.V. – OR4, Axelsedam 3a 4531HH Terneuzen Netherlands
  • Cardolite Specialty Chemicals Europe NV, Wijmenstraat 21 K bus 2 B-9030 Mariakerke (Gent) Belgium
  • Cardolite Specialty Chemicals Europe NV (OR for IXE), Wijmenstraat 21 K bus 2 B-9030 Mariakerke (Gent) Belgium
  • Cardolite Specialty Chemicals Europe NV (OR for ZUH), Wijmenstraat 21 K bus 2 B-9030 Mariakerke (Gent) Belgium
  • CCD (Germany) GmbH, Graf-Adolf-Strasse 68 40210 Düsseldorf Germany
  • ChemADVISOR Europe sprl (client number no: 367), Rue Joseph Stevens 7 Office 1409 B-1000 Brussels Belgium
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Unit 1 Ardee Business Park, Hale Street Co. Louth Ardee Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Jiangsu Sanmu Group Co., ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(EPOXY BASE ELECTRONIC MATERIAL CORPORATION LIMITED), Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited(Jiangsu Kumho Yangnong Chemical Co.,Ltd.), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemservice GmbH - (L4T9), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • CIECH Sarzyna Spółka Akcyjna, ul. Chemikow 1 37-310 Nowa Sarzyna Podkarpackie Poland
  • Cytec Engineered Materials GmbH in its legal capacity as OR of Cytec Industries Inc., Industriestraße 3 76684 Östringen Germany
  • Cytec Engineered Materials Ltd., Abenbury Way Wrexham Industrial Estate LL13 9UZ Wrexham United Kingdom
  • Dexerials Europe B.V., Singaporestraat 9-11 1175 RA Lijnden Noord-Holland Netherlands
  • DOW BENELUX B.V. OR-5, Postbus 48 4530 AA Terneuzen Netherlands
  • DSM Coating Resins B.V., Ceintuurbaan 5 8022 AW Zwolle Netherlands
  • DSM Desotech bv, Slachthuisweg 30 3151 XN Hoek van Holland Netherlands
  • ELANTAS Europe S.R.L., Strada Antolini n.1 43044 Collecchio, frazione Lemignano (PR) Emilia-Romagna Italy
  • ENVIGO CRS SAU 087, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • EQUIPOS NUCLEARES, S.A, Juan Carlos I, nº 8 39600 Maliaño Cantabria Spain
  • ExponentOR29G, Kanzlerstraße 4 D-40472 Düsseldorf Germany
  • Harke Services GmbH-OR9, Xantener Str.1 45479 Mülheim an der Ruhr Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Hexion B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Hexion GmbH, Varziner Str. 49 47138 Duisburg North Rhine-Westphalia Germany
  • Huntsman Advanced Materials (Europe) BVBA, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Advanced Materials (Europe) BVBA OR-C, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Advanced Materials (Europe) BVBA OR-U, Everslaan 45 B-3078 Everberg Belgium
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • KIST Europe Forschungsgesellschaft mbH, Campus E 71 Saarbruecken 66123 Germany
  • LEUNA-Harze GmbH, Am Haupttor, Bau 6619 D-06237 Leuna Germany Germany
  • LOPOUR a syn, s.r.o., Trýbova 968/10 602 00 Brno Czech Republic
  • LORD Germany GMBH, Ottostrasse 28 41836 Hueckelhoven North Rhine - Westphalia Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • NAM & NAM Europe GmbH, Emil-Figge-Str. 80 44227 Dortmund(002) Germany
  • NAMA Germany, Teichstrasse 38 D-79539 Lörrach Germany
  • Pall Europe Ltd, 5 Harbourgate Business Park Southampton Road PO6 4BQ Portsmouth Hampshire United Kingdom
  • Penman Consulting bvba 09, Avenue des Arts 10 B-1210 Brussels Belgium
  • PPG Coatings BV, Papesteeg 102 4006 WC Tiel Netherlands
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Sinopec Europa GmbH, Messe Turm, Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • SSI Technologies s.r.o., Přestanov 113 40317 Přestanov Czech Republic
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • SUEZ Water Technologies & Solutions Hungary Ltd., Bláthy Ottó u. 4. , P.O. Box 100 2840 Oroszlány Hungary
  • THREE BOND EUROPE, 26 avenue des bethunes 95310 SAINT OUEN L'AUMONE France
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Industrie Service GmbH, Westendstraße 199 80686 München Germany
  • UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany
  • Henkel Electronic Materials (Belgium) N.V., Nijverheidsstraat 7 2260 Westerlo Belgium

Other names

  • -
  • 2,2' (1 methylethylidene) bis (4,1-phenyleneoxymethylene) bisoxirane
  • 2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
  • 2,2'-[propane-2,2-diylbis(4,1-phenyleneoxymethylene)]dioxirane
  • 2,2-Bis(4-glycidyloxyphenyl)propane
  • 2-(4-{2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl}phenoxymethyl)oxirane
  • 2-[[4-[2-[4-(oxiran-2-ylmethoxy) phenyl]propan-2-yl]phenoxy]methyl]oxirane
  • 2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
  • 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane
  • 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
  • 4,4'-Methylendiphenyldiglycidylether
  • BADGE
  • bis-[4-(2,3-epoxipropoxi)phenyl]propane
  • Bisphenol A diglycidyl ether
  • Bisphenol A epoxy resin
  • bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700)
  • Bis[4-(2,3-epoxy propoxy) phenyl] propane
  • bis[4-(2,3-EPOXYPROPOXY)PHENYL]PROPANE
  • DER 332 Epoxy Resin
  • DIGLYCIDYL ETHER OF BISPHENOL A
  • Public name: reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700)
  • Reaction mass of meso-2-{ [4-(2-{ 4-[(oxiran-2-yl)methoxy]phenyl} propan-2-yl)phenoxy]methyl} oxirane and (2RS)-2-({ 4-[2-(4-{ [(2RS)-oxiran-2-yl]methoxy} phenyl)propan-2-yl]phenoxy} methyl)oxirane
  • reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight <= 700)
  • reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight <=700)
  • Reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700)
  • Reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700) (BADGE)
  • Reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700), or 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane, or Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis
  • 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
  • bis-[4-(2,3-epoxipropoxi)phenyl]propane
  • 2-(chloromethyl)oxirane; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
  • 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
  • D.E.R.(TM) 330 Liquid Epoxy Resin
  • D.E.R.(TM) 331 Liquid Epoxy Resin
  • D.E.R.(TM) 331(TM) Liquid Epoxy Resin
  • D.E.R.(TM) 331P Liquid Epoxy Resin
  • D.E.R.(TM) 332 Liquid Epoxy Resin
  • D.E.R.(TM) 337 Semi-solid Epoxy Resin
  • D.E.R.(TM) 383 Liquid Epoxy Resin
  • DGEBA
  • EC01
  • EPICLON 840
  • EPICLON 840-LV
  • EPICLON 840-S
  • EPICLON 840-SS
  • EPICLON 850
  • EPICLON 850-CRP
  • EPICLON 850-LC
  • EPICLON 850-S
  • EPIDIAN 4
  • EPIDIAN 4R
  • EPIDIAN 4S
  • EPIDIAN 5
  • EPIDIAN 5S
  • EPIDIAN 6
  • EPIDIAN 6D
  • EPIDIAN 6R
  • EPIDIAN 6S
  • EPIDIAN 6SD
  • EPIKOTE(TM) 828-LVEL
  • Epilox A 17-01
  • Epilox A 18-00
  • Epilox A 19-00
  • Epilox A 19-02
  • Epilox A 19-03
  • Epilox A 19-04
  • Epilox A 25-02
  • Epilox A 32-02
  • Epilox M 600
  • Epilox M 631
  • Epoxy resin
  • GY 2600
  • jER827
  • jER828
  • jER828EL
  • jER828P
  • jER828US
  • jERYL6810
  • Lapox AR-101
  • Lapox-B-11
  • Phenol, 4,4'-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane
  • RAZEEN LR (any other numbers)
  • RAZEEN LR 1100
  • RAZEEN LR 1150
  • Reaction mass of meso-2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2yl)phenoxy]methyl}oxirane and (2RS)-2-({4-[2-(4-{[(2RS)-oxiran-2yl]methoxy}phenyl)propan-2-yl]phenoxy}methyl)oxirane
  • Technical bisphenol a diglycidyl ether
  • YD-128

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [3]
C Form
Viscous (100%) [3]
C Odour
Slight (100%) [3]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
-16 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-16 °C

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Density
1.15 - 1.17 g/cm³ @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.16

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 2 studies processed
R Log Pow
2.64 - 3.78 @ 25 °C and pH 7 - 7.1 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.242 @ 25 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
5.4 - 8.4 mg/L @ 20 °C and pH 6.12 - 6.64 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
6.9 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
60 mN/m @ 3 mg/L

Flash point

Study results
  • 1 study submitted
  • 1 study processed
R Flash point
264 - 268 °C @ 102.89 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
266 °C

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 6 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
10 - 12 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
11 000 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
6.44 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
6.44 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
4.875 days @ 25 °C

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
31 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
445

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 6 µg/L (1)
Intermittent releases (freshwater) 18 µg/L (1)
Marine water 600 ng/L (1)
Intermittent releases (marine water) 1.8 µg/L (1)
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 341 µg/kg sediment dw (1)
Sediment (marine water) 34.1 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 64.7 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 11 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 1.2 - 3.6 mg/L [5]
LC50 (72 h) 1.7 - 1.8 mg/L [3]
LC50 (48 h) 1.85 - 2.7 mg/L [3]
LC50 (24 h) 2.4 - 4.4 mg/L [3]
LC0 (4 days) 1 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
2 mg/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 1.1 - 2.8 mg/L [3]
EC50 (24 h) 4.6 mg/L [1]
LC50 (48 h) 2.7 mg/L [1]
LC50 (24 h) 4.9 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
1.8 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 300 µg/L [1]
LOEC (21 days) 1 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
300 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 9.4 - 11 mg/L [2]
EC50 (48 h) 9.1 mg/L [1]
NOEC (72 h) 2.4 - 4.2 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
11 mg/L
EC10 or NOEC for freshwater algae
4.2 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
IC50 (3 h) 100 mg/L [1]
EC10 (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
100 mg/L
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.93 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 750 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 870 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 89.3 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 14 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 - 15 000 mg/kg bw (rat) [2]
LD50 19 800 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Category 5 based on GHS criteria [2]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC0 (5 h) 0 ppm (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 9 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
LD50 20 mL/kg bw (rabbit) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

dermal
Studies with data
Key study 2
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 15 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 23 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 14
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 14
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 15
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 50 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 50 mg/kg bw/day (chronic, rat)
Dermal route - systemic effects:
Adverse effect observed NOAEL 100 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 26 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 23
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
Adverse effect observed (positive)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 750 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 180 mg/kg bw/day (subacute, rabbit)
Dermal route:
No adverse effect observed NOAEL 300 mg/kg bw/day (subacute, rabbit)

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant