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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was not conducted under GLP or guideline, but uses generally accepted, scientifically valid methods.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Exposure was conducted at saturated atmosphere.
GLP compliance:
no
Test type:
other: Limit test in saturated atmosphere
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Test substance- 1675-54-3

Test animals

Species:
rat
Strain:
other: Albino
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Details on inhalation exposure:
Single inhalation exposure, 5 hours
Substantially saturated atmosphere generated by allowing open vessel to equilibrate in 19 L glass jar exposure chamber (assumed to be maximum attainable concentration)
6 animals/dose level, usually male albino rats
14-day observation period
Duration of exposure:
5 h
Concentrations:
0.000008 ppm (saturated atmosphere)

Saturated atmosphere was calculated based on a vapor pressure of 0.0006 e-6 at 25C and 760 mmHg to be 7.89ppt.
No. of animals per sex per dose:
Six males
Control animals:
no
Details on study design:
Six males were exposed for 5 hours to a substantially saturated atmosphere, then observed for 14 days. Mortality and clinical signs were recorded. Test was terminated after 14 days. Animals were not examined post-mortem.
Statistics:
N/A

Results and discussion

Effect levels
Dose descriptor:
LC0
Effect level:
0 ppm
Exp. duration:
5 h
Remarks on result:
other: LC0= 0.000008 ppm
Mortality:
Breathing saturated vapors was not fatal to rats during a five-hour exposure.
Clinical signs:
None recorded.
Body weight:
No effect
Gross pathology:
Examination not conducted.

Applicant's summary and conclusion

Conclusions:
The LC0 in rats is ~0.000008 ppm.