Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-823-5
CAS number: 1675-54-3
The % inhibition for the test substance was 6, 10, 6, 9 and 10% for concentrations of 2.15, 3.30, 13.0, 32.5 and 109 mg/l.
The IC50 for the reference substance, 3,5 -dichlorphenol, was 13 mg/l.
This study determined the inhibitory concentration of TK 10490 on the respiration of aerobic waste water bacteria. The test lasted for 3 hours at 20 +/-2C. The IC50 was >100 mg/l, the highest concentration tested.
Based on an activated sludge respiration inhibition study, the 3-hour IC10 and IC50 for BADGE and BADGE-related resins is 100 mg/L and > 100 mg/L, respectively.
Two microorganism studies were examined for BADGE and both were deemed
reliable and useful for risk assessment. One study examined the response
of respiration inhibition of activated sludge over a 3 hour exposure
period, while the other study measured growth inhibition of Pseudomonas
putida over an 18-hour exposure period. The
activated sludge inhibition test reported a 3-hour IC20, IC50 and IC80
all >100 mg/L BADGE. Furthermore, inhibition of
respiration did not exceed 10% at the highest dose level (nominal) of
109 mg/L BADGE. According to the study report and the
growth inhibition study with P. putida reported an 18-hour NOEC
of 42.6 mg/L BADGE. The value of 100 mg/L was selected
as the key parameter for this endpoint, since according the ECHA
guidance (R.22.214.171.124.1), the results of the cell multiplication
inhibition test with P. putida should be used for calculation of
the PNECmicro-organisms only in cases where no other test results are
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again