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EC number: 216-823-5 | CAS number: 1675-54-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-05-30
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- EEC L 133, p. 118-122 (30 May 1988) (Deviations- 1) a settled sludge was used 2) due to the poor solubility at test concentrations, direct weighed amounts were added to the test medium instead of a stock
- GLP compliance:
- no
- Analytical monitoring:
- no
- Details on sampling:
- not applicable
- Test organisms (species):
- other: industrial activated sludge
- Details on inoculum:
- Activated sludge was collected from the sewage treatment plant and prepared according to the guideline. The sludge was separated from the aqueous layer by settling instead of centrifugation.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Nominal and measured concentrations:
- nominal- 2.15, 3.3, 13, 32.5, and 109 mg/L.
- Details on test conditions:
- Activated sludge was collected from the sewage treatment plant and prepared according to the guideline. The sludge was separated from the aqueous layer by settling instead of centrifugation. Flasks (250 mL BOD) with gas inlet were used as test vessels. Declorinated drinking water (20 +/- 2C) were used for the 3 hour test.
The test material concentrations were: 2.15, 3.3, 13, 32.5, and 109 mg/L. The sludge concentration was 1.5 g/L.
Oxygen consumption per hour was determined and recorded in mg/L with ORION-Electrode type 97-08 Microprocessor Ionalizer 901.
The inhibitory concentrations were calculated based on the measured time-dependent oxygen consumption of a blank and test solutions. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol at 3.2, 10 and 32 mg/L
- Duration:
- 3 h
- Dose descriptor:
- other: IC20
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibitions were calculated on the basis of the measured time depend oxygen consumption of a blank and test solution.
- Remarks on result:
- other: no data
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibitions were calculated on the basis of the measured time depend oxygen consumption of a blank and test solution.
- Remarks on result:
- other: no data
- Duration:
- 3 h
- Dose descriptor:
- other: IC80
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibitions were calculated on the basis of the measured time depend oxygen consumption of a blank and test solution.
- Remarks on result:
- other: no data
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibitions were calculated on the basis of the measured time depend oxygen consumption of a blank and test solution
- Details on results:
- Graphically determined data
- Results with reference substance (positive control):
- IC50=13 mg/L
- Conclusions:
- Under these test conditions the IC50 is >100 mg/L.
- Executive summary:
This study determined the inhibitory concentration of TK 10490 on the respiration of aerobic waste water bacteria. The test lasted for 3 hours at 20 +/-2C. The IC50 was >100 mg/l, the highest concentration tested.
Reference
The % inhibition for the test substance was 6, 10, 6, 9 and 10% for concentrations of 2.15, 3.30, 13.0, 32.5 and 109 mg/l. The IC50 for the reference substance, 3,5 -dichlorphenol, was 13 mg/l. |
Description of key information
Based on an activated sludge respiration inhibition study, the 3-hour IC10 and IC50 for BADGE and BADGE-related resins is 100 mg/L and > 100 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Two microorganism studies were examined for BADGE and both were deemed reliable and useful for risk assessment. One study examined the response of respiration inhibition of activated sludge over a 3 hour exposure period, while the other study measured growth inhibition of Pseudomonas putida over an 18-hour exposure period. The activated sludge inhibition test reported a 3-hour IC20, IC50 and IC80 all >100 mg/L BADGE. Furthermore, inhibition of respiration did not exceed 10% at the highest dose level (nominal) of 109 mg/L BADGE. According to the study report and the growth inhibition study with P. putida reported an 18-hour NOEC of 42.6 mg/L BADGE. The value of 100 mg/L was selected as the key parameter for this endpoint, since according the ECHA guidance (R.7.8.1.7.1), the results of the cell multiplication inhibition test with P. putida should be used for calculation of the PNECmicro-organisms only in cases where no other test results are available.
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