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EC number: 216-823-5
CAS number: 1675-54-3
The 48 and 72 hour EC50 values were 9.1 and
9.4 mg/L, respectively.
The toxicity of EPIKOTE 828 to S.
capricornutum was determined in a 72 h growth test. Based upon analyses
of the test results in terms of the area under the culture growth curves
the 48 and 72 EC50 values were calculated to be 9.1 and 9.4 mg/L,
respectively, when expressed in terms of the concentration of the
water-soluble fraction of EPIKOTE 828.
In a growth inhibition test with Scenedesmus capricornutum, the 72-hour ErC50 for BADGE and BADGE-related resins was determined to be > 11 mg/L, which was the limit of solubility for BADGE. The 72-hour NOEC (based on growth rate) for BADGE and BADGE-related resins was determined to be 4.2 mg/L.
Two toxicity tests were assessed for this endpoint, and these studies
were found to be of good quality and reliable for use in the risk
assessment process. The two algal toxicity studies that were deemed of
good quality and reliable for use in risk assessment (Klimisch score = 1
or 2) measured both growth rate (r) and biomass (y) as
indicators of growth inhibition over 72 hours of exposure. One
of these reliable studies tested BADGE with Scenedesmuscapricornutum and
reported the NOEC and ErC50 for growth rate as 4.2 and
>11 mg/L BADGE, respectively. The 72-hour ErC50
value (based on growth rate) could not be exactly determined since no
significant effects were noted at the limit of solubility for the test
material. The 72-hour NOEC and EyC50
(based on biomass) in this same study with S. capricornutum were
reported as 2.4 and 9.4 mg/L BADGE, respectively. In
the other reliable algal toxicity test with Pseudokirchneriella
subcapitata, the 72-hour ErC10 and ErC50
for growth rate was reported as 4.51 and >100 mg/L BADGE, respectively.
As in the previous study, the ErC50 value for the specific
growth rate could not be exactly determined due to effects occurring
above the limit of solubility. The 72-hour EyC10
andEyC50 based on biomass was reported as 1.96 and
13.81 mg/L BADGE, respectively, for P. subcapitata. Since
the use of the average specific growth rate for estimating toxicity is
scientifically preferred (OECD 201, 2006), this endpoint was used to
select the key parameter, and the data from the algal toxicity test with S.
capricornutumwas used since the toxicity values in this study were
lower than the reported values for P. subcapitata.
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