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EC number: 216-823-5
CAS number: 1675-54-3
Three 48 hour static toxicity tests were conducted with Daphnia magna.
The test material was delivered by either direct additon, with
sonication, and with an acetone carrier solvent. The resulting EC50
values (based on immobility) were determied to be in the range of 1.1 -
2.8 mg/L, which was within the range of water solubility for the test
At 48 hours, all of the D. magna had died at
3 mg/L while none had died at 1 mg/L. The 48 h EC50 value from the
acute toxicity test was 1.7 mg/L.
A 48 hour static toxicity test was carried
out with Daphnia magna. Test vessels were made in a series of
concentrations ranging from 0.1-10 mg/L with reconstituted fresh water. D.
magna (less than 24 hours old) were placed in 150 ml glass dishes
containing 100 ml of test solution, with 10 animals per dish and 3
replicate dishes per treatment. After 24 and 48 hours, the numbers of
immobilized daphnia were recorded. The 24 hour EC50 was 4.6 mg/L and the
48 hour EC50 was 1.7 mg/L.
The 24- and 48 -hour LC50 was 4.9
and 2.7 mg/L, respectively.
The acute toxicity of EPIKOTE 828 to D.
magna was determined in a 48 h static test i.e. without renewal of the
test media. Based upon the results of the test the 24 and 48 h EC50
values, expressed in terms of the concentration of the water-soluble
fraction of EPIKOTE 828 present in the test medium, were calculated to
be 4.9 and 2.7 mg/L, respectively.
The 48-hour EC50 value of 1.8 mg/L for BADGE and BADGE-related resins is the geometric mean of five 48-hour EC50 values taken from valid exposure studies with BADGE and Daphnia magna.
Six acute toxicity studies with Daphnia magna were
assessed for this endpoint, and five of these studies were found to be
of good quality and reliable for use in the risk assessment process. One
study was deemed not reliable (Klimisch score = 3) due to insufficient
data and the fact that the test material was reported to have come out
of solution and was not wholly soluble at the concentrations tested. Of
the five studies that were deemed of good quality and reliable for use
in risk assessment (Klimisch score = 1 or 2), one study was only 24
hours in duration, and was therefore classified as a supporting study,
and not a key study. Three studies reported 48-hour
EC50 values ranging from 1.1 to 2.8 mg/L and one study reported a
48-hour EC50 value of 51.8 mg/L BADGE. Since one EC50
value was significantly greater than the other values, this data point
was not factored into the calculation of a geometric mean for
determining the 48-hour EC50 value for D. magna. This
was in accordance with ECHA guidance (R.10.2.2) which states that if
toxicity values are more than one order of magnitude different for the
same species, it is questionable whether the data point should be
incorporated together into the geometric mean calculation for that
species and endpoint. In this case, although not
reported in the study, it is probable that the test material was added
to the test vessels at concentrations well above its water solubility,
therefore the EC50 value of 51.8 mg/L BADGE was not incorporated into
the geometric mean calculation. Thus, the key
parameter for the freshwater invertebrate studies was the EC50 value of
1.8 mg/L, which was the geometric mean of five 48-hour EC50 values (1.1,
1.4, 1.7, 2.7, and 2.8 mg/L) reported in three studies with D. magna.
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