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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not stated
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1958

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rabbits were orally gavaged with test material and observed for 10 days. Survivors were sacrificed and necropsied with selected tissues saved for histopathologic examination.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
EPON 828 (25068-38-6)
Purity- No data reported

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
male
Details on test animals and environmental conditions:
male albino rabbits (2.0-3.2 kg).

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
acetone
Details on oral exposure:
Single intragastric administrations were given to male albino rabbits (2.0-3.2 kg). Due to high viscosity, EPON 828 was delivered as a 95% solution with 5% acetone.
Doses:
No additional information provided.
No. of animals per sex per dose:
No additional information provided.
Control animals:
not specified
Details on study design:
Single intragastric administrations were given to male albino rabbits (2.0-3.2 kg). Due to high viscosity, EPON 828 was delivered as a 95% solution with 5% acetone. The animals were observed for the following 10 days, and survivors were necropsied. Sections of tissues were preserved in formalin for histologic examination. LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948) or the method of Weil (1952).

Litchfield, J. T., Jr., and Wilcoxon, F.; A Simplified Method of Evaluating Dose-Effect Experiments, J Pharmacol. & Exper. Therap. 96:99-113, 1949.

Weil, C. S.: Tables for Convenient Calculation of Median Effective Dose and Instructions for Their Use, Biometrics, 8:249-263, 1952.
Statistics:
LD50 values were calculated according to the method of Litchfield and Wilcoxon (1948) or the method of Weil (1952).

Litchfield, J. T., Jr., and Wilcoxon, F.; A Simplified Method of Evaluating Dose-Effect Experiments, J Pharmacol. & Exper. Therap. 96:99-113, 1949.

Weil, C. S.: Tables for Convenient Calculation of Median Effective Dose and Instructions for Their Use, Biometrics, 8:249-263, 1952.

Results and discussion

Preliminary study:
No preliminary study conducted.
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
19 800 mg/kg bw
Remarks on result:
other: Given 95% EPON 828 in 5% acetone.
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
Gross pathology was nonspecific, and the chief effect was that of local irritation.
Other findings:
The LD50 was reported to be 19,800 mg/kg. There are no specific observations or findings noted for EPON 828.

Any other information on results incl. tables

The LD50 was reported to be 19,800 mg/kg. There are no specific observations or findings noted for EPON 828.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
The LD50 in male rabbits given 95% EPON 828 in 5% acetone was reported to be 19,800 mg/kg .
Executive summary:

The LD50 in male rabbits given 95% EPON 828 in 5% acetone was reported to be 19,800 mg/kg .