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EC number: 216-823-5
CAS number: 1675-54-3
The Mean +/- SD DPM for the control, 0.3, 1, 3, 10 and 30% DER-331
groups was 1251 +/-525, 1117 +/- 247, 1381 +/- 465, 1886 +/- 646, 6807
+/-2893 and 14801 +/-4173, respectively.
screening study, mice were treated with three daily applications of
0.5%, 1%, 5%, 10%, 20% or 30% DER-331. Erythema
was absent and body weights were unaffected in all dose groups.
on the results of the screening study, 0.3%, 1%, 3%, 10% or 30% DER-331
was tested in the LLNA to characterize the dose response. Erythema
was absent, and body weights were unaffected in all dose groups.
NOEL for the mouse LLNA was observed with a test concentration of 3%
concentration that would cause a 3-fold increase in proliferation (EC3)
was calculated to be 5.7% which is consistent with moderate dermal
sensitization potential as described by an expert ECETOC panel
(Technical Report No. 87, 2003).
DER-331 was examined in the local lymph node
assay (LLNA). Groups of mice were treated with dose levels of 0.3, 1, 3,
10 and 30% DER-331 in AOO (4:1 acetone:olive oil) for 3 consecutive
days. On day 6, mice were injected with 3H-thymidine and 5 hours later
incorporation of radiolabelled material in the auricular lymph nodes was
determined. A NOEL for the mouse LLNA was observed with a test
concentration of 3% DER-331. The concentration that would cause a 3-fold
increase in proliferation (EC3) was calculated to be 5.7% which is
consistent with moderate dermal sensitization potential.
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