Registration Dossier
Registration Dossier
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EC number: 214-703-7 | CAS number: 1187-93-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to Annex XI section 2, testing for a specific endpoint may be omitted if it is technically not possible to conduct the study as a consequence of the properties of the substance.
According to OECD TG No. 209 Activated Sludge Respiration Inhibition Test (2010) "valid results with volatile chemicals may only be obtained providing that the bulk (say > 80%) of the test substance remains in the reaction mixture at the end of the exposure period(s)".
PMVE is a gas with a limited water solubility, resulting in a very high Henry’s Law Constant (HLC) (32000 Pa m3/mol). The HLC of PMVE indicates that, in a system water-atmosphere, PMVE would tend to rapidly leave the water phase distributing to the atmosphere. This makes the performance of a valid and meaningful Activated Sludge Respiration Inhibition Test unfeasible as a stable concentration of the substance in water is anticipated to be not reachable.
Reference
Description of key information
The study has not be conducted as, based on the physico-chemical properties of PMVE a valid and meaningful study is anticipated to be unfeasible.
In fact, according to the OECD TG No. 209 (Activated Sludge Respiration Inhibition Test, 2010) "valid results with volatile chemicals may only be obtained providing that the bulk (say>80%) of the test substance remains in the reaction mixture at the end of the exposure period(s)".
In a system water-atmosphere, PMVE is anticipated to rapidly leave the water phase distributing to the atmosphere. This makes the performance of a valid and meaningful Activated Sludge Respiration Inhibition Test unfeasible as a stable concentration of the substance in water is anticipated to be not reachable.
Key value for chemical safety assessment
Additional information
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