Registration Dossier
Registration Dossier
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EC number: 202-980-7 | CAS number: 101-83-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
Additional information
In an OECD reproduction/developmentaltoxicity screening test(OECD TG 421) in rats DCHA revealed effects on reproduction only in females at the highest oral dose tested (80 mg/kg bw/day) including slightly reduced gestation index, increase in stillborn pups and decrease in live born pups. Thus, the NOAEL (reproductive toxicity) is 80 mg/kg bw/day for males and 40 mg/kg bw/day for females. The NOEL (offspring) is 40 mg/kg bw/day based on significant reduction in pup weights on day 0 and slight reduction in pup weights on dayoffspring of the parents dosed with 80 mg/kg bw/day. These adverse effects on the development of the F1-generation occur only in the presence of severe maternal toxicity (17 % mortality; 1 of 10 surviving dams without live pups; poor maternal behavior and nursing).
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
Justification for classification or non-classification
Based on the test results and according to the EC criteria for classification and labelling requirements for dangerous substances and mixtures the test substance does not have to be classified for reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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