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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other: other type of company data
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
2 rabbits (male and female), 500 μ/l one ear of the rabbit fixed with a plaster, the other ear served as control, rising post exposure, reading 24h, 48h, and d2, 4, 5, 6, 7, post exposure observation time:7d
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dicyclohexylamine
EC Number:
202-980-7
EC Name:
Dicyclohexylamine
Cas Number:
101-83-7
Molecular formula:
C12H23N
IUPAC Name:
N-cyclohexylcyclohexanamine
Details on test material:
DCHA undiluted, purity >99 % w/w

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24h
Observation period:
24,48h
2, 4, 5, 6, 7d
Number of animals:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritation parameter:
erythema score
Basis:
animal: 2/2
Time point:
72 h
Reversibility:
not specified
Remarks on result:
not measured/tested
Irritation parameter:
erythema score
Basis:
animal: 2/2
Time point:
48 h
Score:
4
Max. score:
4
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Basis:
animal: 2/2
Time point:
24 h
Score:
4
Max. score:
4
Reversibility:
not specified
Remarks on result:
positive indication of irritation

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Remarks:
Migrated information Criteria used for interpretation of results: EU