Registration Dossier
Registration Dossier
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EC number: 202-980-7 | CAS number: 101-83-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficient information to take into account for evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
- Author:
- Filov VA
- Year:
- 1 968
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 7, 29-33
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other:
- Principles of method if other than guideline:
- 2 rats were exposed to vapor (concentration not mentioned); then amine concentration in blood was determined.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Duration and frequency of treatment / exposure:
- 80min.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
No data
- No. of animals per sex per dose / concentration:
- 2
- Control animals:
- not specified
Results and discussion
Main ADME results
- Type:
- absorption
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
- Details on distribution in tissues:
- 0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: raedily absorbed after oral application
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