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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Sufficient information to take into account for evaluation.

Data source

Reference
Reference Type:
publication
Title:
Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
Author:
Filov VA
Year:
1968
Bibliographic source:
Gig. Tr. Prof. Zabol. 7, 29-33

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline available
Guideline:
other:
Principles of method if other than guideline:
2 rats were exposed to vapor (concentration not mentioned); then amine concentration in blood was determined.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
2 animals were exposed for 80 minutes via inhalation, with no data on doses

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: air
Duration and frequency of treatment / exposure:
80min.
Doses / concentrations
Remarks:
Doses / Concentrations:
No data
No. of animals per sex per dose:
2
Control animals:
not specified
Details on study design:
no details
Details on dosing and sampling:
no details
Statistics:
no details

Results and discussion

Main ADME results
Type:
absorption

Toxicokinetic / pharmacokinetic studies

Details on absorption:
0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Details on distribution in tissues:
0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Details on excretion:
no data

Metabolite characterisation studies

Metabolites identified:
not specified
Details on metabolites:
no data

Bioaccessibility

Bioaccessibility testing results:
no data

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: penetrated the alveolar membrane and entered blood stream
Executive summary:

Following inhalation exposure to DCHA, it was determined in blood indicating that dicyclohexylamine penetrates the alveolar membrane and enters the blood.