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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data on putiry of TS, no data on GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
6 male Sprague-Dawley Albino rats were exposed to dicyclohexylamine vapor; concentration: 1.4 mg/l
Chamber temperature: 27 degree C
Chamber humidity: 80 %
Chamber volume: 35 l
Air flow rate: 4.0 l/min
Vaporized sample: 2.1 g
Record of signs of intoxication, gross autopsy
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
dicyclohexylamine vapor;
concentration: 1.4 mg/l
Chamber temperature: 27 degree C
Chamber humidity: 80 %
Chamber volume: 35 l
Air flow rate: 4.0 l/min
Vaporized sample: 2.1 g
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
concentration: 1.4 mg/l
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.4 mg/L air
Based on:
not specified
Exp. duration:
6 h
Mortality:
Mortality: 0/6
Clinical signs:
slight lethargy during exposure; no toxic signs following exposure
Body weight:
no data
Gross pathology:
none reported

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LC50> 1.4 mg/l
Executive summary:

LC50> 1.4 mg/l, no deaths occured, no gross pathology recorded, slight lethargy was reported during exposure; with no toxic signs following exposure