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EC number: 202-980-7 | CAS number: 101-83-7
- Life Cycle description
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Dicyclohexylamine showed no mutagenic activity in a standard Ames test with and without metabolic activation system but induced chromosomal aberrations in Chinese hamster (CHL) cells at high concentrationsand short exposure time (exposure time: 6 hours (a) with S9-mix at 0,6 mg/ml; (b) without S9-mix at 0,8 and 1.0 mg/ml).
Using EU Method B.12, Mutagenicity – In vivo Mammalian Erythrocyte Micronucleus Test,DCHA induced the production of the micronuclei, with are the result of chromosomal damage to the mitotic apparatus in the erythroblasts of the rats. Based on the results of available in vitro and in vivo tests, DCHA belongs to mutagens.
Under the conditions of the Mouse Bone Marrow Erythrocyte Micronuleus Test, a single oral administration of Dicyclohexylamine at doses up to and including 200 mg/kg did not induce a significant increase in the incidence of micronucleated polychromatic erythrocytes in bone marrow. Therefore, Dicyclohexylamine was concluded to be negative in the micronucleus test using male ICR mice (Krsmanovic, L., Ph.D., Divi, K., M.S., 2010,Kastenbaum, M.A., Bowman, K.O., 1970).
Endpoint Conclusion:
Justification for classification or non-classification
Available data are inconclusive; a testing proposal for mutagenicity has been submitted.
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