Registration Dossier
Registration Dossier
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EC number: 202-980-7 | CAS number: 101-83-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No histopatological evaluation
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Single oral application by gavage, undiluted TS., 5 doses, observation time 14d, determination of signs of intoxication, stat.method:probit analysis.
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
- Based on:
- not specified
- Mortality:
- Dose: number of dead rats (time of death)// number of rats with symptoms
0.16 ml/kg bw: 0/10 (-) // 10/10
0.18 ml/kg bw: 1/10 (3h) // 10/10
0.20 ml/kg bw: 5/10 (3h) // 10/10
0.25 ml/kg bw: 7/10 (3h) // 10/10
0.30 ml/kg bw: 10/10 (2h-2d) // 10/10 - Clinical signs:
- other: tonical cramps, sedation, poor general condition
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was 200 mg/kg bw.
- Executive summary:
The oral LD50 in the rats was 200 mg/kg bw. Signs of intoxication were tonical cramps, sedation, poor general condition
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