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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No histopatological evaluation

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Deviations:
not specified
Principles of method if other than guideline:
Single oral application by gavage, undiluted TS., 5 doses, observation time 14d, determination of signs of intoxication, stat.method:probit analysis.
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dicyclohexylamine
EC Number:
202-980-7
EC Name:
Dicyclohexylamine
Cas Number:
101-83-7
Molecular formula:
C12H23N
IUPAC Name:
N-cyclohexylcyclohexanamine

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
200 mg/kg bw
Based on:
not specified
Mortality:
Dose: number of dead rats (time of death)// number of rats with symptoms
0.16 ml/kg bw: 0/10 (-) // 10/10
0.18 ml/kg bw: 1/10 (3h) // 10/10
0.20 ml/kg bw: 5/10 (3h) // 10/10
0.25 ml/kg bw: 7/10 (3h) // 10/10
0.30 ml/kg bw: 10/10 (2h-2d) // 10/10
Clinical signs:
other: tonical cramps, sedation, poor general condition
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was 200 mg/kg bw.
Executive summary:

The oral LD50 in the rats was 200 mg/kg bw. Signs of intoxication were tonical cramps, sedation, poor general condition