Registration Dossier
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EC number: 202-980-7 | CAS number: 101-83-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Performance description is not in compliance with an actual guideline, result description is incomplete as e.g. individual animal results are not shown
Data source
Reference
- Reference Type:
- publication
- Title:
- On the toxicity of cyclohexylamine and dicyclohexylamine.
- Author:
- Lomonova GV
- Year:
- 1 963
- Bibliographic source:
- Gig. Tr. Prof. Zabol 7, 51-56.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- doses 0.11 mg/l/2 h
- Duration of treatment / exposure:
- 30d
- Frequency of treatment:
- daily
- No. of animals per sex per dose:
- No data
- Details on study design:
- not available
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- other: not specified
- Effect level:
- ca. 0 other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: ability to swim
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The exposure period was tolerated without visible clinical symptoms.
Post exposure, treated mice were able to swim as long as untreated control mice.
Applicant's summary and conclusion
- Conclusions:
- Inconclusive study, reliability 4, scarce data available
- Executive summary:
30 day inhalation study in mice. Crucial information not available.
The exposure period was tolerated without visible clinical symptoms.
Post exposure, treated mice were able to swim as long as untreated control mice.
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