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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data on purity, different number of rabbits/group.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other:
Principles of method if other than guideline:
4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure; TS undiluted; post application observation period: 14 days, record of signs of intox., gross autopsy
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure;
Duration of exposure:
24h
Doses:
126, 200, 316, 501
No. of animals per sex per dose:
4 dose groups: 126 mg/kg (1 male), 200 mg/kg (2 males and 3 females), 316 mg/kg (1 female), 501 mg/kg (1 male); 24-h exposure;
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
200 - 316 mg/kg bw
Mortality:
time of mortality: within 16 hours
Clinical signs:
reduced appetite and activity (2-3 days in survivors), increasing weakness, collapse, and death
Gross pathology:
dead animals 0 hemorrhagic areas of the lungs, liver discoloration, enlarged gall bladder, and gastrointestinal inflammation
survivors: viscera appeared normal

Any other information on results incl. tables

dosage    initial weight (kg)      Mortality
mg/kg
       male  female         male  female

126
        2.0             -             0/1     -
200
        2.0            2.4          1/2    0/3
316
         -             2.1             -     1/1
501
        2.1             -             1/1     -

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 200 - 316 mg/kg bw.
Executive summary:

LD50: 200-316 mg/kg bw (male/female), reduced apetite and activity repoerted for survivors.