Registration Dossier

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Sufficient information to take into account for evaluation

Data source

Reference
Reference Type:
publication
Title:
Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
Author:
Filov VA
Year:
1968
Bibliographic source:
Gig. Tr. Prof. Zabol. 7, 29-33.

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other:
Principles of method if other than guideline:
2 ml rat liver homogenate was mixed with 8 ml physiologic solution containing 0.04 mg/ml for 1 hr.
Rabbit liver slice (8 cm²) was exposed to 20 ml physiologic solution containing 0.08 mg/ml for up to 18 hrs
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
not specified

Test animals

Species:
other: rat, rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
18h
Doses:
20 ml physiologic solution containing 0.08 mg/ml
No. of animals per group:
No data
Control animals:
no

Results and discussion

Any other information on results incl. tables

No change in the concentration of dicyclohexylamine detected.

Applicant's summary and conclusion