Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-980-7 | CAS number: 101-83-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficient information to take into account for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
- Author:
- Filov VA
- Year:
- 1 968
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 7, 29-33.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other:
- Principles of method if other than guideline:
- 2 ml rat liver homogenate was mixed with 8 ml physiologic solution containing 0.04 mg/ml for 1 hr.
Rabbit liver slice (8 cm²) was exposed to 20 ml physiologic solution containing 0.08 mg/ml for up to 18 hrs - GLP compliance:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: rat, rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 18h
- Doses:
- 20 ml physiologic solution containing 0.08 mg/ml
- No. of animals per group:
- No data
- Control animals:
- no
Results and discussion
Any other information on results incl. tables
No change in the concentration of dicyclohexylamine detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
