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EC number: 202-436-9
CAS number: 95-63-6
In the first
generation parental body weights were significantly reduced at 1500 ppm
but reproductive parameters were unaffected. There were no differences
in litter size, mean birth weight, or postnatal survival. Once maternal
exposures were reinitiated (at day 4L), offspring in the 1500 ppm group
gained weight more slowly than controls.
In the second
generation parental body weight gain was again reduced at 1500 ppm and,
male fertility was lower. Litter size, birth weight, and postnatal
survival appeared to be reduced in the 1500 ppm exposure group although
this was affected by the inclusion of several litters exposed beyond
GD20, until just prior to birth. In these litters, the frequency of live
births and mean birth weight was reduced and survival early in lactation
was poor. Litters from dams exposed to 1500 ppm to GD20 pup survival was
92.5% compared with 98.7% in controls.
For the third
generation, exposure of each rat was continuous (i.e. there was no
exposure-free period between weaning and commencement of exposure as in
previous generations). In the 1500 ppm group, 88% of the rats
died. There was no evidence of fertility or reproductive effects
although only 6 litters were available for evaluation at 1500 ppm. Birth
weights were lower in the 1500 ppm group although mean body weight at
LD4 was not different from control. The toxicity of 1500 ppm in this
generation precludes definitive evaluation of the potential for
reproductive effects and clarification of the results obtained in the
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