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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The reported 96hr LC50 for Pimephales promelas (Fathead Minnows)  was experimentally determined to be 7.72mg/l (Geiger D.L. et al, 1986)

Key value for chemical safety assessment

LC50 for freshwater fish:
7.72 mg/L

Additional information

Based on the information available the study by Gieger et al, 1986, can be considered the key study. The study has a reliability rating of 2 because the source predates implementation of GLP and development of study guidelines, however the procedure and means of analysis suggest that the methodology was appropriate to evaluate the short term toxicity to fish. There is otherwise no information in the article to suggest that the data are invalid. The result does not indicate that 1,2,4-trimethylbenzene would meet the criteria for toxic in the PBT assessment. This endpoint would not affect the classification of the 1, 2, 4-trimethylbenzene since the substance is biodegradable and the log Kow is < 4.0.

Supporting studies based on a QSAR calculation and an unassignable MITI (1997) report give 96 hr LC50 values of 3.4 and 18 mg/l respectively.