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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non-guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
as described by Noakes DN and Sanderson DM (1969), A method for determining the dermal toxicity of pesticides. Br. J. Indust. Med., 26, 59-64
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Solvent naphtha (petroleum), light arom.
EC Number:
265-199-0
EC Name:
Solvent naphtha (petroleum), light arom.
Cas Number:
64742-95-6
IUPAC Name:
64742-95-6
Constituent 2
Reference substance name:
Shellsol A
IUPAC Name:
Shellsol A
Details on test material:
- Name of test material (as cited in study report): Shellsol A
- Substance type: hydrocarbon solvent (essentially C9 isomers, particularly trimethylbenzenes)
- Physical state: liquid
- Source: Shell Nederland Raffinarderij B.V. refinery, Pernis, Rotterdam, The Netherlands

Test animals

Species:
rat
Strain:
other: CD (COBS)
Sex:
male/female
Details on test animals or test system and environmental conditions:
- Source: Charles River (UK) Ltd., Manston, Kent, UK
- Age at study initiation:no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS: no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
1, 2, 4 mL/kg bw
No. of animals per sex per dose:
2
Control animals:
no
Details on study design:
- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
Statistics:
not applicable

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 other: mL/kg bw (3440 mg/kg)
Remarks on result:
other: no mortalities at 4 mL/kg bw (highest dose tested)
Mortality:
no mortalities
Clinical signs:
none

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 of Shellsol A was greater than 4 mL/kg bw to male and female rats.
Executive summary:

The acute dermal toxicity of Shellsol A was low, the 24 hour LD50 in rats was greater than 4 mL/kg bw to male and female rats (i.e. >3440 mg/kg).