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EC number: 202-436-9
CAS number: 95-63-6
The 48 hour LC50 for Daphnia magna was experimentally determined to be 3.6 mg/l (Bobra et al, 1983).
Based on the information available the Bobra
et al, 1983 study is considered to be the key study. The study has a
reliability rating of 2 because it is a non-GLP; non-guideline study,
published in peer reviewed literature with minor restrictions in design
and/or reporting but otherwise adequate for assessment. There is
otherwise no information in the article to suggest that the data are
result does not indicate that 1,2,4-trimethylbenzene would meet the
criteria for toxic in the PBT assessment. This endpoint would not affect
the classification of the 1, 2, 4-trimethylbenzene since the substance
is biodegradable and the log Kow is < 4.0.
A supporting study by Abernathy et al, 1986
reports a 24 hr LC50 for Artemia of 12.0 mg/l. A QSAR calculation using
the ECOSAR model gives an estimated 48 hr LC50 for Daphnids of
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