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EC number: 202-436-9
CAS number: 95-63-6
Six male volunteers were exposed to 200 mg/m3 1,3,5 -trimethylbenzene
vapours for 4 hours to determine the kinetics of elimination of
unchanged 1,3,5 -trimethylbenzene in urine. Urine samples were collected
before exposure, every 2 hours of exposure, and up to 24 hours from the
start of exposure. In the subsequent study, six male volunteers were
exposed to 20, 60, and 100 mg/m3 1,3,5 -trimethylbenzene vapours for 8
hours. Blood samples were collected before exposure and 30 minutes after
the end of the exposure. Urine samples were collected before exposure
and for the final two hours of the exposure period. The elimination
kinetics of 1,3,5 -trimethylbenzene in urine followed an open
two-compartment model with the half-life values of 0.45 and 6.68 hours
for the first and second phases, respectively. There was a linear
relationship between the air concentration of 1,3,5-trimethylbenzene and
the concentration of unchanged substance and its metabolite
3,5-dimethylbenzoic acid in urine as well as the unchanged substance in
blood. Unchanged 1,3,5-trimethylbenzene in urine was found to be a more
precise method than those based on the unchanged substance in blood or
its metabolite in urine.
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