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EC number: 202-436-9
CAS number: 95-63-6
During the first 3 hours
1,2,4-trimethylbenzene was toxic to all three sludges to different
extends, based on inhibition of oxygen uptake compared to the control
(endogenous respiration rate). Brookside was the most effected, followed
by Hillard, with Columbus activated sludge being only minimally
effected. Inhibition (toxicity) was indicated by a negative oxygen
uptake. In longer aeration periods, 5-7.5 days, 1,2,4-trimethylbenzene
was significantly biodegraded (oxygen uptake about 2000 mg/L). Of all
the polymethylated benzenes, 1,2,4-trimethylbenzene is the only one to
be significantly biologically oxidized and is more susceptible to
oxidation than o-xylene.
This robust summary has a reliability rating
of 2, because it is a non-GLP; non-guideline study, experimental study
and predates implementation of GLP and/or development of study
guidelines however, the procedure and means of analysis suggest that the
methodology was appropriate to evaluate the required endpoint. There is
otherwise no information in the article to suggest that the data are
invalid. However, because the study did not follow recommended
guidelines the interpretation of the results cannot be fully assessed
against the guideline criteria and therefore the result is only an
indication of inhibition.
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