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EC number: 202-436-9
CAS number: 95-63-6
Log Kow of 1,2,4-trimethylbenzene is 3.63.
Partition coefficient values for this substance are cited in a number of
reliable, peer-reviewed secondary data sources. A weight of evidence
approach has been used to fill this endpoint based on the data from
these secondary sources. A log Kow value of 3.63 is cited in Hansch
(1995, citing Doucette and Andren, 1988), Lide (2008) and in the CODATA
database (citing Wasik et al 1981). This same value taken from Hansch
(1995) is also used in the training data set of the USEPA KOWWIN QSAR
(USEPA 2008). As this QSAR is widely accepted by Regulators, we believe
this demonstrates that the data used to develop the model should also be
considered reliable. It appears that at least two separate original
sources are being cited in these four data sources. The CODATA database
also contains a number of log Kow values for this substance from
different primary sources. These log Kow results available in the
database are 3.58 (Mackay et al 1980), 3.78 (Hammers et al 1982), 3.91
(Sherblom et al 1988) and 3.65 (Guo et al 1996). Hansch (1995) also
cites the value of 3.78 from Hammers et al 1982.
The reported log Kow values range from 3.58 -3.91 and are therefore
within a narrow range. They do not span any criteria used to define the
appropriate classification of the substance or its bioaccumulation
potential. As a number of different primary references are cited by
these authoritative data sources we believe that the use of these data
is justifiable to fulfil this data requirement.
The log Kow value of 3.63 is identified as the key value for the risk
assessment as the method and temperature were stated in the secondary
source (CODATA database), two separate publications have reported this
value (Wasik et al 1981 and Doucette and Andren 1988), it is reported by
several secondary sources, and this value was also used in the training
set of the USEPA KOWWIN model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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