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EC number: 202-436-9
CAS number: 95-63-6
is no information on sensitisation in humans after exposure to
animals a key study is provided by Shell Toxicology Laboratory (1977).
Guinea pigs were challenged with Shellsol A (a mixture of
trimethylbenzenes CAS No 64742 -95 -6) in a maximization test. No
sensitisation response was elicited immediately, 24 or 48 hours after
the challenge. The test was therefore negative. This result is supported
by a poorly reported guinea pig maximization test (IUCLID 4 record;
EBSI, 1983) where no sensitisation occurred after exposure to
1,2,4-trimethylbenzene (study unavailable).
contrast, dermal responses were reported when Aromasol H (a mixture of
C8 aromatics (xylenes and benzenes), C9 aromatics (trimethylbenzenes and
ethyl toluenes), and C10 aromatics (diethyl ethyl benzenes and diethyl
benzenes) was tested in a guinea pig maximization test (CTL1984). The
study report concluded that Aromasol H was a weak sensitizer but
irritation was also noted. Irritation has been reported to be a factor
in false positive results obtained on other substances in the guinea pig
maximization test (Basketter, 2008). The substituted aromatics present
in Aromasol H are known to be non-sensitising, hence the weight of
evidence therefore indicates that this result is a false positive.
conclusion, the available evidence indicates that 1,2,4-trimethylbenzeneis
not a skin sensitiser.
D (2008). Information derived from sensitization test methods: Test
sensitivity, false positives, and false negatives. Reg. Tox. Pharm. 50,
is not considered to be sensitizing. It does not therefore warrant
classification under DSD or CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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