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EC number: 202-436-9
CAS number: 95-63-6
1,3,5-Trimethylbenzene was administered at
dose levels of 0, 50, 200 and 600 mg/kg/day to 10 male and 10 female
Sprague Dawley CD rats for 90 days. An additional 10 rats/sex were dosed
at 600 mg/kg/day group on the same dosing schedule but were subsequently
retained without treatment for an additional 28 days to evaluate
recovery from any toxic effects.
In the 600 mg/kg/day group an increase in
serum phosphorus levels (males and females), liver weight increase
(absolute and relative weight increase in females; relative increase
only in males) and kidney weight increase in males were reported. In the
recovery group, no apparent effects were reported at the end of the
28-day recovery period.
Based on the recovery group data, the
effects reported at the highest dose were considered reversible and were
attributed to adaptive response (enzyme induction) to the test
substance. In the liver this could be attributed to microsomal enzymes
induction while in the male rat kidney, to a-2µ-globulin related
nephropathy. With respect to the elevated serum phosphorus levels
observed, these levels werenot statistically different at the end of the
28 -day recovery period and no associated histopathological effects were
reported which could be correlated with the increased serum phosphorus
levels. The NOAEL for this study can therefore be concluded to be 600
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