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EC number: 202-436-9
CAS number: 95-63-6
Rats were exposed to a
50:50 blend of SHELLSOL A and SOLVESSO 100 at exposure concentrations of
0, 450, 900 and 1800 mg/m3 for 12 months. Initial reduction in body
weight gain occurred in both male and female rats at the higher
exposures. Various statistically significant haematological changes were
transiently seen in males up to six months, but were not considered
biologically significant. High exposure male liver and kidney weights
were increased at 6 and 12 months but, in the absence of
histopathological changes, were considered to be physiological adaptive
responses. No treatment-related histopathological abnormalities were
found. It is concluded that chronic exposure to this high aromatic
naphtha is without systemic toxicity in rats under the conditions of
this study with a NOAEC of 1800 mg/m3.
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