Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
April 7, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Dermal absorption estimated using modeling program (US EPA's Estimation Program Interface) recommended in the REACH Guidance.

Data source

Materials and methods

Principles of method if other than guideline:
Dermwin module (v1.43), EPI v3.20
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Dermal absorption was modeled based on DBDPEthane's chemical structure.
Radiolabelling:
no

Test animals

Species:
other: none
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Type of coverage:
other: not applicable
Vehicle:
other: not applicable
Duration of exposure:
not applicable
Doses:
not applicable
No. of animals per group:
not applicable
Control animals:
no

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not specified
Absorption in different matrices:
Dermal absorption of DBDPEthane is not expected. Dermwin v1.43 estimates dermal absorption of 3.2E-15 mg/cm2-event using Fick's first law of diffusion or 5.6E-9 mg/cm2-event using equations contained in the program.
Total recovery:
not applicable
Percutaneous absorption
Remarks on result:
other:

Applicant's summary and conclusion

Conclusions:
Dermal absorption of DBDPEthane is not expected. Dermwin v1.43 estimates dermal absorption of 3.2E-15 mg/cm2-event using Fick's first law of diffusion or 5.6E-9 mg/cm2-event using equations contained in the program. This is consistent with the high molecular weight and negligible solubility of DBDPEthane.
Executive summary:

Dermal absorption of DBDPEthane is not expected. Dermwin v1.43 estimates dermal absorption of 3.2E-15 mg/cm2-event using Fick's first law of diffusion or 5.6E-9 mg/cm2-event using equations contained in the program. This is consistent with the high molecular weight and negligible solubility of DBDPEthane.