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EC number: 284-366-9
CAS number: 84852-53-9
EBP was demonstrated to be stable and not
biodegrade in several test systems, STP simulation systems, aerobic and
anaerobic sediment and soil studies according to standard OECD test
guidelines (OECD 308 and 307), but with prolonged exposure durations of
6 months. In the sediment it was verified that microorganisms capable of
degrading organo-halogen compounds were present. A recent study in
aerobic soils with 6 plant species also showed no fromation of
metabolites during the 61d exposure period. A study carried out to
mimick recycling in HIPS manufacture containing EBP and EBP and Sb2O3
under realistic worst case conditions and temperatures also revealed
that the substance remained stable and only a minor increase of the Br9
-isomers occurred after 6 recycling cycles. Several studies in polymers
and under incineration conditions have demonstrated that no
polybrominated dioxin or-furans are formed during those processes.
Thus it can be concluded that the substance
itsself is very peristent and does not form degradation products that
could have a higher bioaccumulation or toxicity potential under
environmental conditions or under reasonable worst case use conditions.
recent guideline studies according to OECD 305 and GLP with dietary
exposure were performed following the substance evaluation decision.
These studies demonstrated the extremely
low potential for bioaccumulation of EBP compared to known reference
substances. It could also be confirmed in those studies that the
substance is hardly absorbed from the gastro-intestinal tract and the
low tissue levels are depurated quickly. EBP was also used as a
benchmark chemical that is poorly absorbed in fish by Xiao et al. 2013.
With reagrd to a possible bioaccumulation potential in terrestrial
organisms, several studies have shown that a trophic magnification is
unlikely and the rat toxicokinetic study also suggests very little
absorption and uptake in mammalian tissues after a single oral exposure.
To investigate the uptake after repeated
exposure a testing proposal for toxikokinetics in rats after repeated
exposure has also been made in the last update of this dossier together
with a proposal for an extended one generation study, should
considerable uptake occur.
The substance is not toxic to aquatic
organisms up to the solubility limit. A recent 21 -d Daphnia
reproduction study revealed no effect when tested at the solubility
limit in the test medium. In soil and sediment organisms very high
NOAECs were observed.
L. varigaetus and chironmus, NOEC=5000 mg/kg
sediment dw. Mammalian toxicity studies after single and prolonged
exposure did not reveal adverse effects up to the limit dose of 1000
EBP is very poorly absorbed by all routes of
exposure. It has negligible solubility in water and binds to
particulates which will settle out of solution. Thus, water exposures
are not expected to be significant. It's very low vapor pressure
indicates it will not partition to the gas phase; binding to air
particulates which settle out is likely. Significant exposure via
inhalation is not expected. If present in sewage influent, EBP is likely
to bind to particulates in the sludge. Sludge applied to agricultural
soil may be a route for a transport to that matrix, where EBP will be
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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