1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001-2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Work was not performed under GLPs.

Data source

Reference

Reference 1

Reference Type:

other company data

Title:

Unnamed

Year:

2001

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

2013

Reference 3

Reference Type:

publication

Title:

In vitro and in ovo effects of four bromianted flame retardants on toxicity and hepatic mRNA expression in chicken embryos

Author:

Egloff et al

Year:

2011

Bibliographic source:

Toxicology Letters 201:25-33, page 26

Reference 4

Reference Type:

study report

Title:

Unnamed

Year:

2008

Reference 5

Reference Type:

study report

Title:

Unnamed

Year:

2004

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Standard laboratory methods for determination of solubility were used in the various studies.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]

EC Number:

284-366-9

EC Name:

1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]

Cas Number:

84852-53-9

Molecular formula:

C14H4Br10

IUPAC Name:

1,2,3,4,5-pentabromo-6-[2-(2,3,4,5,6-pentabromophenyl)ethyl]benzene

Test material form:

other: commercial DBDPEthane product or analytical standard supplied in toluene

Details on test material:

Test material commercial DBDPEthane product: Albemarle 2001, Featherstone and Landry 2013, Griffin 2008, Sims 2004
Test material analytical standard supplied in toluene: Egloff et al. 2011

Results and discussion

Solubility in organic solvents / fat solubility

Solubility in organic solvents / fat solubility 1

Medium:

acetone

Solubility:

< 0.01 other: weight %

Temp.:

25 °C

Remarks on result:

other: Albemarle 2001

Solubility in organic solvents / fat solubility 2

Medium:

methanol

Solubility:

< 0.01 other: weight %

Temp.:

25 °C

Remarks on result:

other: Albemarle 2001

Solubility in organic solvents / fat solubility 3

Medium:

toluene

Solubility:

< 0.01 other: weight %

Temp.:

25 °C

Remarks on result:

other: Albemarle 2001

Solubility in organic solvents / fat solubility 4

Medium:

other: chlorobenzene

Solubility:

< 0.01 other: weight %

Temp.:

25 °C

Remarks on result:

other: Albemarle 2001

Solubility in organic solvents / fat solubility 5

Medium:

other: methylene dibromide

Solubility:

< 0.01 other: weight %

Temp.:

25 °C

Remarks on result:

other: Albemarle 2001

Solubility in organic solvents / fat solubility 6

Medium:

other: dimethylformamid

Solubility:

< 0.01 other: weight %

Temp.:

25 °C

Remarks on result:

other: Albemarle 2001

Solubility in organic solvents / fat solubility 7

Medium:

n-octanol

Solubility:

850 µg/L

Temp.:

23 °C

Remarks on result:

other: Featherstone and Landry 2013

Solubility in organic solvents / fat solubility 8

Medium:

DMSO

Solubility:

0.02 mg/L

Remarks on result:

other: Egloff et al. 2011; GCMS(ECNI); suspension allowed to settle & measured in supernate; test material was analytical standard supplied in toluene

Solubility in organic solvents / fat solubility 9

Medium:

DMSO

Solubility:

> 0.325 - <= 0.625 other: microM

Remarks on result:

other: Cyprotex 2008; LC-UV; ambient temp; test material was commercial DBDPEthane product

Solubility in organic solvents / fat solubility 10

Medium:

other: cell culture buffer solution (HHanks Balanced Salt Solution)

Solubility:

< 0.128 other: microM

Remarks on result:

other: Cyprotex 2008; LC-UV; ambient temp; test material was commercial DBDPEthane product

Details on results:

The results are continued in the second record for this endpoint.

Any other information on results incl. tables

Summary Table (records .001 and .002).

SOLVENT	Solubility		Method	Source
	Units as Originally Reported	μg//L
Acetone	<0.01 wt%	<10000	GC	ALB 2001
	<0.01 mg/mL	<10	HPLC-UV	RTI 2012
Methanol	<0.01 wt%	<10000	GC	ALB 2001
Toluene	<0.01 wt%	<10000	GC	ALB 2001
	40 ug/mL	40000	HPLC-UV	RTI 2012
Chlorobenzene	<0.01 wt%	<10000	GC	ALB 2001
Methylene dibromide	<0.01 wt%	<10000	GC	ALB 2001
DMF	<0.01 wt%	<10000	GC	ALB 2001
n-Octanol	0.85 ppm	850	HPLC-UV	ALB 2013
DMSO	0.02 mg/L	20*	GCMSECNI	Egloff 2011
	>0.325<0.625 μM	>0.325<0.625	HPLC-UV	Cyprotex 2008
	<0.1 mg/mL	<100	HPLC-UV	RTI 2012
Ethanol	<0.01 mg/mL	<10	HPLC-UV	RTI 2012
Chloroform	0.005 mg/mL	<5	HPLC-UV	RTI 2012

*Determined for an analytical standard supplied in toluene.

Applicant's summary and conclusion

Conclusions:

The solubility of DBDPEthane in 10 organic solvents has been assessed in several laboratories using a variety of analytical methods. DBDPEthane shows very limited solubility in all 10 solvents.

Executive summary:

The solubility of DBDPEthane in 10 organic solvents has been assessed in several laboratories using a variety of analytical methods. DBDPEthane shows very limited solubility in all 10 solvents.