Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-366-9
CAS number: 84852-53-9
A peak was detected at the same position as
that of the test substance on the IC chromotogram of the control fish
both before initiation and at study termination. To take the unknown
into account, the range between the maximum and minimum value of the
peak's size was used as the minimum limit of detemination (2.l98 - 1.71
= 1.27 ug/g). The measured values in fish were corrected for the
unknown. Based on the minimum limit of determination, the minimal BCFs
that could be calculated in the study were 2.5 (Level 1) and 25 (Level
2). These minimal BCFs indicate the study was able to detect BCF of
concern (e.g. >2000 and >5000).
Measured concentrations in test water
(mg/L); average value at the time elapsed from starting of exposure
Concentration of test substance in each fish (μg/g) by week of test.
N.D.= Not Detected; a: minimal limit of determination = 1.27 ug/g at a
fish weight of 30 g.
Calculated BCFs in each fish by week of study.
DBDPEthane did not bioconcentrate in fish(Cyprnus
carpio)when tested over an 8 week period. Evidence for the
bioconcentration of DBDPEthane was not observed.The reported
bioconcentration factors (BCF) were < 2.5 and <25 at a water
concentration of 0.5 mg/L and 0.05 mg/L, respectively, at the end of an
8 week exposure period. The reported BCF values were based on the
minimal BCF possible due to the presence of an interferring peak in the
controls and nondetectable levels in exposed fish at the majority of
time points. (Levels just below the minimal detection limit was report
in 1 fish at the upper dose at 8 wks, and 1.74 ug/g bw was detected in 1
fish at the lower dose at week 2. At all other time points
concentrations in fish were below the limit of dtermination.)
The analytical method, specific for
bromide ions, would have detected the presence of parent molecule plus
metabolites (if any). The lack of bioconcentration observed in this
study is consistent with the expectation that exposures to DBDPEthane
via water will be low and uptake will be poor.
This study has been criticized because a) an
interferring peak in control fish increased the detection limit and b)
exposure concentrations were higher than DBDPE'thane's water solubility
(~0.72 ug/L) determined many years later. The final report stated that
the minimal detectable BCF was 2.5 (level 1) and 25 (Level 2). These
minimal BCF are below a level of concern with respect to
bioconcentration, and from this standpoint the study was capable of
measuring a BCF of concern. However, both exposure concentrations were
substantially higher than DBDPEthane's measured water solubility, which
limits the utility of calculating a BCF from the water concentrations.
Because of this, the reported BCF will not be used in the CSR.
We point out that in the wild C. carpio are
primarily selective benthic omnivores that specialize in invertebrates
that live in sediments (Makiguchi et al. 2012, http://animaldiversity.ummz.umich.edu/accounts/Cyprinus_carpio/).
They feed by sucking up mud from the bottom, ejecting it, and then
selectively consuming re-suspended items. Carp engage in this activity
to the extent of decreasing water quality. It cannot be excluded that
some exposure occurred due to the carps' suction feeding mode.
DBDPEthane will adsorb to particulates in the water (food, feces), which
would then settle to the bottom of the aquaria. The carps' natural
feeding behavior could then result in dietary exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again