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EC number: 284-366-9
CAS number: 84852-53-9
20 wk avian reproduction test
DEMETRA (REACH Guidance, Chapter R.7C) predicts the substance's acute
oral LD50 for 14 day exposures in Bob White quail to be > maximum of the
database with a minimum value of 7,192 mg/kg bw and a maximum value of
23,770 mg/kg bw. Thus, the substance is not expected to be acutely toxic
in avians. This is consistent with mammalian results indicating a lack
of acute toxicity. The substance is expected to a have a low potential
for bioaccumulation based on its physical/chemical properties of low
solubility, high adsorption, low log Kow and high molecular weight, and
pharmacokinetic data. Field data indicates a lack of
bioaccumulation/biomagnification. The UK RAR on the substance reported
a risk characterization ratio for fish eating predadors of <0.1.
The results of a 20 week avian reproduction test demonstrate a lack of
chronic toxicity, no effects on reproduction, and no detectable egg
residues (LOD= 1 mg/kg ww in albumin or yolk). No treatment-related
mortality, overt signs of toxicity, or effects on body weight, feed
consumption or reproductive parameters at any dietary concentrations
tested (160, 400, 1000 ppm a.i.) were observed. Reproductive parameters
included number of eggs laid, fertility, embryo viability, hatchability,
offspring survival, and egg shell thickness. Hatchling body weight was
not affected by parental treatment. The no-observed-effect concentration
for northern bobwhite exposed to S8010 in the diet was 1000 ppm a.i.
(88.1 mg a.i./kg bw/day), the highest concentration tested. Analysis of
egg albumin and yolk collected from birds in the control and 1000 ppm
diet groups at weeks 2, 6, 9 and 10 of egg production had no detectable
residues of the test substance. These weeks of egg production correspond
to 12, 16, 19 and 20 weeks dietary administration of the test substance
to adult birds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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