Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the
reproductive effects of the test substance administered orally by gavage
to Crl:COBSCD(SD) BR rats for two generations according to a method
similar to OECD Guideline 416. Dose levels of 25, 200, 500 and 600 mg/kg
bw/day were administered daily for 404 d. There were no effects on the
viability of pups from dams dosed at 25 or 200 mg/kg bw/day. In
addition, there was no effect on mating, fertility, gestation, delivery
of pups, or lactation index at these dose levels. Under the study
conditions, mortality, reduced weight gain in adults and slight increase
in pup mortality (first generation only) was observed at 500 mg/kg
bw/day. Therefore, the the
parental NOAEL was 500 mg/kg bw/day and the reproductive NOAEL
and LOAEL were 200 and 500 mg/kg bw/day, respectively (Argus, 1982).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again