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EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the
reproductive effects of the test substance administered orally by gavage
to Crl:COBSCD(SD) BR rats for two generations according to a method
similar to OECD Guideline 416. Dose levels of 25, 200, 500 and 600 mg/kg
bw/day were administered daily for 404 d. There were no effects on the
viability of pups from dams dosed at 25 or 200 mg/kg bw/day. In
addition, there was no effect on mating, fertility, gestation, delivery
of pups, or lactation index at these dose levels. Under the study
conditions, mortality, reduced weight gain in adults and slight increase
in pup mortality (first generation only) was observed at 500 mg/kg
bw/day. Therefore, the the
parental NOAEL was 500 mg/kg bw/day and the reproductive NOAEL
and LOAEL were 200 and 500 mg/kg bw/day, respectively (Argus, 1982).
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