Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-562-2 | CAS number: 25013-15-4
Long-term toxicity to fish
Administrative data
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The substance falls within the applicability domain of the selected (Q)SAR method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPI SUITE ECOSAR v 1.0 and 1.11
Test material
- Reference substance name:
- Vinyltoluene
- EC Number:
- 246-562-2
- EC Name:
- Vinyltoluene
- Cas Number:
- 25013-15-4
- Molecular formula:
- C9H10
- IUPAC Name:
- Reaction mass of 3-methylstyrene and 4-methylstyrene
- Test material form:
- liquid
Constituent 1
Test organisms
- Test organisms (species):
- other: Saltwater fish (species unspecified)
Study design
- Test type:
- other: chronic toxicity study (assume to 30 day)
- Water media type:
- saltwater
- Total exposure duration:
- 30 d
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 30 d
- Dose descriptor:
- other: ChV
- Effect conc.:
- 1.636 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: QSAR
- Key result
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.16 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Details on results:
- The estimated toxicity to a salt water fish species using the EPA ECOSAR model is 1.636 mg/L (ChV). According to ECHA Guidance on information requirements and chemical safety assessment Chapter R.10, if in the test report only the ChV is presented, the ChV can be divided by √2 to derive a NOEC. 1.636 mg/L was divided by root 2 to give a NOEC value of 1.160 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Under the study conditions, the 30 d NOEC for marine fish was therefore considered to be 1.160 mg/L.
- Executive summary:
A study was conducted to determine the chronic toxicity of the test substance to marine fish using the EPI SUITE ECOSAR v 1.0 and 1.11 model. The ChV corresponds to the geometric mean of the NOEC and LOEC. Thus, according to ECHA REACH Guidance R.10, the ChV can be divided by √2 to derive a NOEC. In this case 1.636 mg/L was divided by root 2 to give a NOEC value of 1.160 mg/L. Under the study conditions, the 30 d NOEC for marine fish was therefore considered to be 1.160 mg/L (US EPA, 2017).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
