Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-562-2
CAS number: 25013-15-4
Subchronic NOAEC (rat, male/female): 60 ppm (289.57 mg/m3 based on molecular weight of 118 g/mol). (Similar to OECD 413, GLP)
In a subchronic inhalation toxicity study (Similar to OECD 413/GLP) Vinyl toluene (approx. 99%; p-Vinyl toluene (31.6%) and m-vinyl toluene (68.4%)) was administered to 10 male and female F344/N rats by dynamic whole body exposure at concentrations of 0, 25, 60, 160, 400, or 1,000 ppm for 6 hours per day, 5 days/week for a total of 13 weeks .
All rats lived to the end of the studies. The final mean body weights of rats exposed to 160, 400, or 1,000 ppm were 6%, 8%, or 19% lower than that of controls for males and 5%, 6%, or 12% lower for females. Excessive lacrimation, palpebral closure, and rough hair coats were seen in rats exposed to 1,000 ppm. Relative liver weights, but not absolute weights, for rats exposed to 1,000 ppm were significantly greater than those for controls, but were not associated with histopathological changes. A mild nephropathy characterized by increased tubular casts was found in male rats exposed to 160, 400, or 1,000 ppm. No compound-related lesions were observed in female rats. There were no reports of local effects.
The NOAEC value of both sexes was considered to be 60 ppm (289.57 mg/m3 based on molecular weight of 118 g/mol). The LOAEC value for both sexes was considered to be 160 ppm.
This subchronic inhalation toxicity study in the rat is acceptable and satisfies the guideline requirement for a subchronic inhalation study OECD 413 in the rat.
The key study was the only study available.
In a sub-chronic inhalation toxicity study (Similar to OECD 413/GLP), vinyl toluene (approx. 99%; p-Vinyl toluene (31.6%) and m-vinyl toluene (68.4%)) was administered to 10 male and female F344/N rats by dynamic whole body exposure at concentrations of 0, 25, 60, 160, 400, or 1,000 ppm for 6 hours per day, 5 days/week for a total of 13 weeks.
Based on available information in the dossier, the substance vinylt
toluene (CAS No. 25013 -15 -4) does not need to be classified as
specific target organ toxicity (repeated) when considering the criteria
outlined in Annex I of 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
За да гарантираме, че се възползвате максимално от функциите на нашия уебсайт, сме въвели „бисквитки“.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again