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EC number: 246-562-2
CAS number: 25013-15-4
In a subchronic inhalation toxicity study (Similar to OECD 413/GLP) Vinyl toluene (approx. 99%; p-Vinyl toluene (31.6%) and m-vinyl toluene (68.4%)) was administered to 10 male and female F344/N rats by dynamic whole body exposure at concentrations of 0, 25, 60, 160, 400, or 1,000 ppm for 6 hours per day, 5 days/week for a total of 13 weeks .
All rats lived to the end of the studies. The final mean body weights of rats exposed to 160, 400, or 1,000 ppm were 6%, 8%, or 19% lower than that of controls for males and 5%, 6%, or 12% lower for females. Excessive lacrimation, palpebral closure, and rough hair coats were seen in rats exposed to 1,000 ppm. Relative liver weights, but not absolute weights, for rats exposed to 1,000 ppm were significantly greater than those for controls, but were not associated with histopathological changes. A mild nephropathy characterized by increased tubular casts was found in male rats exposed to 160, 400, or 1,000 ppm. No compound-related lesions were observed in female rats. There were no reports of local effects.
The NOAEC value of both sexes was considered to be 60 ppm (289.57 mg/m3 based on molecular weight of 118 g/mol). The LOAEC value for both sexes was considered to be 160 ppm.
This subchronic inhalation toxicity study in the rat is acceptable and satisfies the guideline requirement for a subchronic inhalation study OECD 413 in the rat.
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