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EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the
toxicity of the test substance to Sprague-Dawley rats exposed by
inhalation for 6 h. A group of 5 male and 5 female rats were exposed
(whole body) to the test substance at a nominal concentration of 3500
ppm (i.e. 16891.62 mg/m3, or 17.8 mg/L) and were then observed for 14 d.
Mortality and clinical signs were recorded frequently during and
immediately after exposure and daily thereafter. Body weights were
determined on Day 0 (prior to exposure) and on Days 1, 2, 4, 7 and 14.
At necropsy, a macroscopic examination was performed on all animals.
Under the study conditions, ocular, nasal and oral irritation was noted
during exposure, decreasing 4 h post-exposure. Neuromuscular impairment
was noted after exposure, increasing in severity 4 h post-exposure. All
clinical signs had abated by Day 3. Small transient weight losses were
noted for all animals. Macroscopic findings at necropsy were
unremarkable. The 4 h LC50 was therefore >3500 ppm (i.e. 16891.62 mg/m3
or 17.8 mg/L) (Norvell, 1980).
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