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EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the skin
irritation/corrosion potential of the test substance in rabbits
following a single dermal exposure according to Federal Hazardous
Substances Act, September 27, 1973. Six New Zealand White rabbits (2.05
to 2.15 kg) were dosed dermally with a single application of 0.5 mL of
the test substance. The site of application was clipped and abraded on
all rabbits. Observations were made at 24 and 72 h following application
for signs of irritation and corrosivity. Irritation scores were recorded
and the primary index was calculated. The test substance was applied to
the backs and an occlusive wrap was not used. Reactions were only
measured at 24 and 72 h. At 24 h, 3/6 animals had a score of 2 for
erythema and 3/6 a score of 1. At 24 h, 6/6 had a score of 1. Under the
study conditions, the calculated primary index for the test substance
was 1.5 (Adamik, 1997).
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