Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-562-2
CAS number: 25013-15-4
study was conducted to determine the toxicity of the test substance in
Sprague-Dawley rats. Four groups of 10 male rats were given a single
dose of 0.6, 1.3, 2.5 or 5.0 mL/kg bw. The animals were observed for 14
d and mortality and clinical signs were recorded daily. Body weights
were determined on Day 0 (day of dosing) and on Day 14. Macroscopic
findings were recorded at necropsy of all animals that died or were
killed on Day 14. On the day of dosing, all rats at 2.5 mL/kg and 7/10
rats at 5.0 mL/kg had an increase in respiration rate, slight trembling
throughout the body and were slightly listless while the other 3 rats
were also lying on their side very listlessly. On Days 1 and 2, the rats
that survived in the two highest groups were slightly listless and had a
slight increase in respiration, with the exception of one rat at the
highest dose which was still very listless on Days 1 and 2, and slightly
listless on Day 3. All surviving rats were normal thereafter until Day
14 when one rat at 2.5 mL/kg died. Gross necropsy revealed and enlarged
lobe of the lung which contained a reddish-yellow, foamy fluid. All other
rats were normal on Day 14. Under the study conditions, the calculated
oral LD50 was 3.68 mL/kg bw, with 95% confidence limits of 2.07 to 6.52
mL/kg bw. Based on a relative density of 0.917, this is equivalent to an
LD50 of 3375 mg/kg bw (Adamik, 1977).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again