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EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the acute
dermal toxicity of the test substance according to Federal Hazardous
Substances Act, September 27, 1973. Five groups of 2 male and 2 female
rabbits were given a single non-occluded 24 h application of the test
substance at 0.5, 1.0, 2.0, 4.0 or 5.0 mL/kg bw. The skin of two rabbits
per group was abraded while the skin of remaining two rabbits was left
intact. After 24 h, residual test substance was removed and the animals
were observed for a further 14 d. Mortality and clinical signs were
recorded daily, including examination for signs of skin irritation and
systemic toxicity. Body weights were determined on Day 0 (day of
application) and on Day 14, prior to necropsy. At necropsy, a
macroscopic examination was performed. No mortality occurred in any of
the rabbits during the study and no signs of systemic toxicity or
behavioral changes were noted. At the site of test substance
application, the following findings were noted: slight to moderate
erythema and very slight to slight edema in all groups. These findings
returned to normal during the second week of the observation period,
except in Group 5. Slight fissuring was noted occasionally in two
animals in Group 1 and one animal in Group 2. This finding was
classified as being slight to moderate in Group 5. A dose-related
incidence of coriaceous skin was noted in most animals, with slight
responses in Groups 1, 2, 3 and 4 which returned to normal by the end of
the observation period. Moderate responses of coriaceous skin were noted
in Group 5. In addition, atonia and desquamation were noted in Group 5.
Under the study conditions, the dermal LD50 was determined to be >5.0
mL/kg bw. Based on a relative density of 0.917, this is equivalent to an
LD50 of 4585 mg/kg bw ( Adamik, 1997).
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