Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-562-2
CAS number: 25013-15-4
A study was conducted to determine the acute
dermal toxicity of the test substance according to Federal Hazardous
Substances Act, September 27, 1973. Five groups of 2 male and 2 female
rabbits were given a single non-occluded 24 h application of the test
substance at 0.5, 1.0, 2.0, 4.0 or 5.0 mL/kg bw. The skin of two rabbits
per group was abraded while the skin of remaining two rabbits was left
intact. After 24 h, residual test substance was removed and the animals
were observed for a further 14 d. Mortality and clinical signs were
recorded daily, including examination for signs of skin irritation and
systemic toxicity. Body weights were determined on Day 0 (day of
application) and on Day 14, prior to necropsy. At necropsy, a
macroscopic examination was performed. No mortality occurred in any of
the rabbits during the study and no signs of systemic toxicity or
behavioral changes were noted. At the site of test substance
application, the following findings were noted: slight to moderate
erythema and very slight to slight edema in all groups. These findings
returned to normal during the second week of the observation period,
except in Group 5. Slight fissuring was noted occasionally in two
animals in Group 1 and one animal in Group 2. This finding was
classified as being slight to moderate in Group 5. A dose-related
incidence of coriaceous skin was noted in most animals, with slight
responses in Groups 1, 2, 3 and 4 which returned to normal by the end of
the observation period. Moderate responses of coriaceous skin were noted
in Group 5. In addition, atonia and desquamation were noted in Group 5.
Under the study conditions, the dermal LD50 was determined to be >5.0
mL/kg bw. Based on a relative density of 0.917, this is equivalent to an
LD50 of 4585 mg/kg bw ( Adamik, 1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
За да гарантираме, че се възползвате максимално от функциите на нашия уебсайт, сме въвели „бисквитки“.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again