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EC number: 246-562-2
CAS number: 25013-15-4
In the in vitro eye irritation Bovine Corneal Opacity and Permeability (BCOP) assay (OECD 437/GLP), 3 isolated bovine corneas were exposed to Vinyltoluene (99.66%; 3-Vinyltoluene CAS No. 100-80-1: 64.3 %; 4-Vinyltoluene CAS No. 622-97-9: 35.7 %) in liquid form for 10 minutes using the closed-chamber method. 0.9% sodium chloride was used for the negative control and 1% NaOH solution in highly purified water was used for the positive control. The corneas were rinsed and following a 2-hour post-exposure incubation at 32°C ± 1°C, the opacity and permeability of each cornea was recorded.
The positive and negative controls gave the appropriate response (IVIS = 76.999 ± 10.459 and 0.613 ± 1.731, respectively). The mean opacity value for the test substance was 1.992 ± 0.222. The mean permeability OD490 for the test substance was 0.396 ± 0.134. The IVIS for the test substance was 7.927 ± 2.006. The IVIS for Vinyltoluene is > 3 and simultaneously ≤ 55, therefore the classification according to UN GHS criteria for eye irritation or serious eye damage is: no prediction can be made.
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